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European Infrastructure for Generating, Phenotyping and Archiving of Model Mammalian Genomes (INFRAFRONTIER)
Identification
Hosting Legal Entity
Helmholtz Association
Address:
Germany
Location
Ingolstaedter Landstrasse 1, Neuherberg-Munich, PO: 85764, Bayern (Germany)
Structure
Type Of RI
Distributed
Coordinating Country
Germany
Participating Countries
United Kingdom
Finland
Italy
Germany
Netherlands
Sweden
Austria
Denmark
Czech Republic
Greece
Spain
France
Nodes
Provider Country:
Czech Republic
Czech Center of Phenogenomics
Provider Country:
Finland
University of Oulu
Provider Country:
France
Phenomin-ICS
Provider Country:
Germany
Helmholtz Center Munich
Provider Country:
Greece
BSRC Alexander Fleming
Provider Country:
United Kingdom
MRC Harwell
Status
Status
Current Status:
Operational since 2011
Timeline
Operational since 2011 to 2019
Scientific Description
Europe urgently needs to find solutions for the grand challenges in the area of human health. Mammalian models have proven to be a vital resource for biomedical research to understand human diseases and to develop treatments for them. Mouse studies have been key to breakthrough discoveries in the functional basis of human health and diseases, to pre-clinical screening and drug development.
The INFRAFRONTIER Research Infrastructure provides access to high-quality, high-efficiency resources and data for the development, phenotyping, archiving and distribution of mammalian models. Access is open for individual researchers and for national, European and international research programmes.
The national Mouse Clinics organised in INFRAFRONTIER offer access to a comprehensive first-line systemic phenotypic screening. They are perfectly equipped to provide customised deep-drilling analyses tailored to the specific needs of a research project.

RI Keywords
Phenotyping, Human diseases, Gene therapy, Rare diseases, Ageing, Mouse models
Classifications
RI Category
Animal facilities
Biomedical Imaging Facilities
Scientific Domain
Biological and Medical Sciences
ESFRI Domain
Health and Food
Services
model generation (mouse, rat); systemic and specialised phenotyping; archiving and distribution of mouse models worldwide; extensive training courses

In systemic phenotyping, INFRAFRONTIER and its member institutions support the global research approach of the International Mouse Phenotyping Consortium (IMPC). In specialised phenotyping, the INFRAFRONTIER institutes offer a wide range of individual phenotyping tools to theirs scientific partners. With more than 7,000 mouse strains available, the European Mouse Mutant Archive (EMMA) is Europes biggest repository for mammalian genomes.

Equipment
equipment for standardized phenotyping pipelines and specialised phenotyping research

breeding equipment for mouse model generation; high-end cryopreservation equipment; higly specialised test equipment for research in metabolism, motion, hearing, and other capabilities of the mouse models

Access
Access Type
Mail-in
Access Mode
Excellence Driven
Access Webpage
Users
Number of Users
Number Year
50 2018
Users Definition
Research teams, individual researchers & research institutions (combined)
Type of Users
Academic - 80.0%
Public research organisations - 20.0%
Collaborations
ESFRI
RI is an ESFRI landmark
Date of last update: 15/01/2019