Biomedical Sciences Research Center Alexander Fleming
Systems Biology/Computational Biology Facilities
Genomic, Transcriptomic, Proteomics and Metabolomics Facilities
Translational Research Centres
Fleming, through Infrafrontier-GR, aims to build and operate a state-of-the-art mouse clinic that will include animal housing and phenotyping facilities based on cutting edge technological platforms. The Infrastructure will provide easy access to mouse models and facilitate their dissemination within the Greek research community and abroad. Furthermore, it will provide specialist secondary phenotyping services initially in the field of immunology, as well as in other disease areas and is expected to boost Greek research productivity and innovation potential. Services in secondary phenotyping are specialized and disease-specific and include: Genomics (gene expression profiling and high throughput technologies, including array-based approaches (e.g. Affymetrix) and next-generation deep sequencing platforms (e.g. Illumina) Proteomics (mass-spectrometry platforms allowing whole proteome identification) Imaging (live cell and whole animal imaging capabilities) Bioinformatics (units specializing in the comprehensive analysis of large experimental data sets) Histopathology (unit which performs standardized histological assays, pathological evaluation and documentation) Cytochemistry (units capable of performing flow cytometry-based analysis in large number of samples) Biochemistry and Toxicology (units suitable to measure wide range of metabolites in biological fluids including blood, urine and tissue extracts) Pharmacokinetics (units capable of following the metabolic fates of experimental drugs in mice Evaluation of pharmaceuticals Furthermore the Infrastructure provides state-of-the art archiving and distribution services in accordance with the protocols and standards of the European Mutant Mouse Archive (EMMA), of which Fleming is already a Member. The network will also provide Training on high end technological platforms.