Training on and maintenance of available light microscopes (commercial and developed) at facility.

Recombinant protein production in E. coli or insect cells for research purposes.

Transmission electron microscopy of frozen hydrated specimens (cells, viruses, molecules).

Developing, implementing and applying advanced data analysis tools and novel approaches for the analysis of high-throughput data set generated mainly by next-generation sequencing instruments. The core works closely with the CSF Next-generation sequencing (NGS) facility and provides consultation and downstream data analysis for various NGS applications.

Purification of recombinant protein for research purposes.

Biochemical and biophysical characterization of proteins, using techniques such as Simple Western, Microscale Thermophoresis, and Circular Dichroism.

Developing and implementing hardware-related software for biological experiments using embedded and robotic systems.

Specimen preparation via high pressure freezing and freeze substitution.

Sampling of embryos, perfusion, necropsy, tissue paraffin or cryo-embedding, sectioning of paraffin or cryo blocks, automated basic staining, immunostaining, pathology report.

High throughput sequencing of libraries on Illumina sequencers, first and second level bioinformatic support.

Development of custom high end light microscopy solutions for biomedical research purposes.

Ultrahigh field magnetic resonance imaging at 15.2 T for advanced anatomical and functional characterization of transgenic (mouse) models, both for whole animal screening and for focusing on specific organs; qualitative and quantitative image analysis.

Providing innovative and intuitive software solutions that solve general as well as individual needs for laboratories including scientific and laboratory data management as well as automated data analysis and reporting tools.

Generation of sequencing libraries and quality control.

Provision of state-of-the-art nanoHPLC-MS/MS systems for protein identification, posphomapping and quantification.

Robotic, non-destructive plant phenotyping.

Providing longer general courses and shorter specific trainings as well as consultation support in the fields of biostatistics, programming and bioinformatics by both external and internal experts.

Specimen preparation via chemical fixation and embedding.

Provision of numerous environmental plant growth conditions: Standard growth conditions, frost (down to -15°C), high-temp. (up to 50°C), adjustable light spectrum (LED), different gas conditions, fully automated watering…, Air-Lock System equipped chamber for pathogen infestation experiments; Large Capacity Chamber; Seed Storage Chamber.

Behaviour: spontaneous behavior, motor analysis learning-memory, anxiety-depression, social interactions, pain; Metabolic function: Drinking/feeding behavior, calorimetry, environmental challenges; Neuro-physiological functions: ECG, blood pressure, EEG/EMG.

Immunolabelling of cryosectioned material for Transmission EM.

Leica EM GP: Immersion freezer for cryo-TEM Bal-Tec MED050: High vacuum evaporator with electron guns Bal-Tec BAF400: Freeze fracture unit Leica EM PACT: High pressure freezer * HFP Compact 001: High pressure freezer.

Deltavision OMX v4 (Applied Precision/GE Healthcare), with 405nm, 488nm & 568nm excitation lasers.

Comprises all equipment necessary for culturing of insect cells.

Microtime 200 by Picoquant, with 440nm & 510nm pulsed excitation diodes.

22 high quality, state of the art and highly specialized plant growth chambers: fully automated watering, LED-Chamber for adjustable light spectrum, 4 Frost-Chambers (down to -15°C), High-temp.-Chamber (up to 50°C), Large Capacity Chamber, Air-lock System Chamber, 2 Gas-tight Chambers for different gas conditions, Plant Phenotyping Chamber, Seed Storage Chamber.

12 cage Phenomaster with climate chamber, Motorater, telemetry, 2 video tracking systems, open field, different mazes, fear conditioning, operant learning, analgesia equipment (dynamic plantar test for touch sensitivity and Hot/Cold plate).

Several instruments for biophysical characterization of proteins, including analysis of protein-protein interactions and protein secondary structure.

nanoHPLC-MS systems: 3 Thermo Q-Exactive, 3 Thermo LTQ Orbitrap VELOS+ETD, ABI Triple 5600, AB SCIEX QTrap 5500.

FEI Morgagni: 100 kV TEM FEI Tecnai 20: 200 kV TEM for electron tomography FEI Tecnai F30 Helium ('Polara'): 300 kV FEG TEM for cryo-TEM, electron tomography and EELS.

Bruker 152/11 BioSpec (http://www.bruker.com/fileadmin/user_upload/8-PDF-Docs/MagneticResonance/MRI/brochures/152-11_mouse_T138908.pdf).

Instrument for automated analysis of proteins via capillary electrophoresis combined with immunodetection.

FPLC systems for protein purification.

2x Genome Analyzer IIx (Illumina), 1x HiSeq 2000 (Illumina), 1x HiSeq 2500 (Illumina).