The Isotope Separator On-Line DEvice, ISOLDE, is a facility dedicated to the production of a large variety of radioactive beams, located at the European Organization for Nuclear Research, CERN. Since 1992, the facility is receiving protons at 1.4 GeV from the Proton-Synchrotron Booster (PSB). This energetic proton beam is sent onto a variety of targets to produce exotic radioisotopes via spallation, fragmentation and fission reactions. The ISOLDE facility provides low energy radioactive beams and post-accelerated beams up to 10 MeV/u.In the last 50 years the ISOLDE facility has gathered unique expertise in research with radioactive beams. Over 700 isotopes of more than 70 elements have been used in a wide range of research domains, including cutting edge studies in nuclear structure, atomic physics, nuclear astrophysics, and fundamental interactions. These probes are also used to do frontier research in solid state and life sciences.