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German Mouse Clinic (GMC)
Identification
Hosting Legal Entity
Helmholtz Association
Address:
Germany
Location
Ingolstaedter Landstrasse 1, Infrafrontier GmbH, Neuherberg-Munich, PO: 85764, Bayern (Germany)
Structure
Type Of RI
Single-sited
Coordinating Country
Germany
Status
Status
Current Status:
Operational since 2001
Scientific Description
The German Mouse Clinic was founded in 2001 at the Helmholtz Zentrum München. The goal of the GMC is the characterization of mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies. The GMC follows the strategy to develop and offer a large scale standardized and comprehensive phenotypic analysis of mouse mutants from various sources (transgenes, knockout mice, mutants from mutagenesis screens like ENU). The GMC provides the examination of mouse mutants using a broad standardized phenotypic check-up with more than 500 parameters. The screens in the GMC are designated to the areas of behavior, bone and cartilage development, neurology, clinical chemistry, eye development, immunology, allergy, steroid metabolism (optional), energy metabolism, lung function (optional), pain perception, molecular phenotyping, cardiovascular analyses and pathology.

RI Keywords
Genetic diseases, Screen, Human disease model, Phenotyping, Mouse models
Classifications
RI Category
Collections of Biological Resources (e.g. Microorganisms, Biobanks and Seed Banks)
Animal facilities
Scientific Domain
Biological and Medical Sciences
Services
Mouse phenotyping
Equipment
In-vivo and in-vitro µCT, FACS, MRI, Echo, ECG, X-Ray, DEXA, OCT, pQCT, ABR

In-vivo and in-vitro micro-computed tomography (µCT), Fluorescence-Activated Cell Sorting (FACS), Magnetic Resonance Imaging (MRI), Echocardiography (Echo), Electrocardiography (ECG), X-Ray, Dual Energy X-Ray Absorptiometry (DEXA), Optical Coherence Tomography (OCT), Peripheral Quantitative Computed Tomography (pQCT), Auditory Brain Stem Response (ABR).

Collaborations
Networks
International Mouse Phenotyping Consortium (IMPC)
BioMedBridges
INFRAFRONTIER
Date of last update: 08/02/2014
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