The German Mouse Clinic was founded in 2001 at the Helmholtz Zentrum München. The goal of the GMC is the characterization of mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies. The GMC follows the strategy to develop and offer a large scale standardized and comprehensive phenotypic analysis of mouse mutants from various sources (transgenes, knockout mice, mutants from mutagenesis screens like ENU). The GMC provides the examination of mouse mutants using a broad standardized phenotypic check-up with more than 500 parameters. The screens in the GMC are designated to the areas of behavior, bone and cartilage development, neurology, clinical chemistry, eye development, immunology, allergy, steroid metabolism (optional), energy metabolism, lung function (optional), pain perception, molecular phenotyping, cardiovascular analyses and pathology.