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Nuclear Magnetic Resonance Laboratory (LRB)
Hosting Legal Entity
University of Barcelona
Baldiri i Reixac 10, Barcelona, PO: 08028, Catalunya (Spain)
Type Of RI
Coordinating Country
Current Status:
Operational since 2000
Scientific Description
The Barcelona NMR Laboratory (LRB) offers access to an 800 MHz, two 600 MHz and three 500 MHz NMR instruments and scientific and technical staff of support. It is located in building designed to house high field NMR spectrometers. Our main singularities are the 800 MHz NMR and the Dynamic Nuclear Polarization instruments. One of the 500 MHz NMR machine is equipped with a HRMAS probe for study biological tissues or gel phase samples. The highest sensitivity, needed for low concentration samples is accomplished with the use of cryoprobes on 800 MHz and one 600 MHz instruments. Our instrumental capability is fully supported by the possibility of access to the expression and purification of labelled proteins laboratory next to our facilities.Our facilities offer a global support including choice and design of experiments, experiment set up. Our machines can be used as a tool to check new methods to be implemented at other labs and instruments.The instrumentation together with the collaboration of a highly trained staff provides support to researchers in diverse areas, mainly: Biomolecule structure, Interactions (Pharmaceutical research), Functional Biology, Drug delivery, Structural identification in Organic and Inorganic Chemistry, Food Science and Technology, New methodologies: NMR applications development.This RI is an ICTS (Unique Scientific and Technological Infrastructure), included in the Spanish National Roadmap for RIs.

RI Keywords
Drug discovery, Nuclear magnetic resonance, High throughput ligand screening, NMR methodological studies, Food science and technology, Dynamic nuclear polarization experiments, Protein structure determination, NMR studies in small molecules
RI Category
Materials Synthesis or Testing Facilities
Structural Biology Facilities
Genomic, Transcriptomic, Proteomics and Metabolomics Facilities
Scientific Domain
Chemistry and Material Sciences
Earth and Environmental Sciences
Biological and Medical Sciences
External services

Give advice on NMR application to pharmaceutical industries.

Spectrometer Time

We provide direct access to our spectrometers to the users with previous experience.

Training and Spectrometer access

To facilitate the use to the technique to non NMR expert researchers by training and guided use of high performance NMR instrumentation.

Dynamic nuclear polarization experiments

Study of new radicals and applications.

Protein Structure

Access to the advance pulse sequences in the high field NMR spectrometers.

NMR screening techniques.

- receptor-based screening - ligand-based screening.

Bruker Avance 500 MHz Spectrometer

(year: 1993) upgraded in 2003 500 MHz Oxford Instruments magnet - 3-channel Bruker DMX-500, Gradients in Z - 5mm TXI RT 1H{13C/15N} with,Z-Grad (S/N: 900:1) (2003)- HRMAS Probe, gradients in magic angle.

Bruker Avance 600 MHz Ultra Shielded Spectrometer

(year: 2010)600 MHz Bruker Ultra Shielded Magnet -RF 5 chanels - 5mm TCI CryoProbe 1H{13C/15N} with Z-Grad (S/N > 6000:1) - Gradient in Z. Nitrogen recover systemSpectrometer and CryoProbe acquired with MINECO-FEDER funds.

Varian Inova 500MHz Spectrometer

(year: 1988) upgraded in 1998-2002500 MHz Oxford Instruments magnet - 3-channel Varian Inova console - Waveforms generator in all channels for shaped pulses (1998) - Probes: 5mm Penta probe z PFG 1H-13C-15N-31P (2002), z-PFG 5 mmTriple Resonance Probe 1H{13C/15N} (1998) - Carousel Autosampler This instrument is attached to OIMBL's HypersenseTM system.

Bruker Avance 600 MHz Spectrometer

(year: 2000)600 MHz Bruker Magnet - 5 mm BBFO Probe {BB/19F - 1H/2H}, Zgradients, automatic tunning (ATM) - 5mm TXI RT 1H{13C/15N} with,Z-Grad (S/N: 1700:1) - 5mm TXI RT TXI 1H/13C/31P} with Z-Grad (S/N: 1700:1) - Gradient.

Varian VNMRS 500 MHz Spectrometer

(year: 2008) 500 MHz actively shielded Magnex magnet - 2-channel Varian Direct Drive - Waveforms generator in all channels for shaped pulses - Probes: 1H-19F/15N-31P 5 mm PFG OneNMR Probe (2008); HCN 5mm z-PFG probe (2001),: 5mm Penta probe z-PFG 1H-13C-15N-31P (2002) - SMS AutosamplerSpectrometer acquired with MINECO-FEDER funds.

Bruker Avance 800 NMR Spectrometer

(year: 2000). RF 4 chanels - 800 MHz Bruker sub-cooled Magnet - 5mm TCI CryoProbe 1H{13C/15N} with Z-Grad (S/N: 7000:1) - 5mm TXI RT 1H{13C/15N} with X,Y,Z-Grad (S/N: 1700:1) - 8mm TXI RT 1H{13C/15N} with Z-Grad (S/N: 1700:1) - Gradients in X, Y, Z.

OIMBL's HypersenseTM system for dynamic nuclear polarization experiments

(year: 2007)OIMBL's HypersenseTM system for dynamic nuclear polarization experiments - Oxford Magnet 3,35 Tesla. - This instrument is attached to an NMR spectrometer Varian Inova 500Instrument acquired with MINECO-FEDER funds.

Date of last update: 15/02/2017
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