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French Infrastructure for Integrated Structural Biology (FRISBI)
Identification
Hosting Legal Entity
Institute of Genetics and Molecular and Cellular Biology-Centre for Integrative Biology (IGBMC-CBI)
Address:
1, rue Laurent Fries, Illkirch, PO: 67404, Alsace (France)
Location
1, rue Laurent Fries, Illkirch, PO: 67404, Alsace (France)
Structure
Type Of RI
Distributed
Coordinating Country
France
Nodes
Instruct Centre - France 2 - Integrated Structural Biology Grenoble (ISBG)
Provider Country:
France
South Paris
Provider Country:
France
Architecture et Fonction des Macromolécules Biologiques (AFMB)
Provider Country:
France
Structural Biochemistry Center (CBS)
Provider Country:
France
Instruct Center - France 1 - Institute of Genetics and Molecular and Cellular Biology (IGBMC)
Provider Country:
France
Status
Status
Current Status:
Operational
Contacts
Contact Person
Klaholz Bruno
Scientific Description
The French Infrastructure for Integrated Structural Biology (FRISBI) provides an infrastructure for integrative structural biology approaches from the molecular to the cellular level, integrating multi-resolution data from X-ray crystallography, small angle X-ray scattering, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and functional data including development for protein expression and crystallization.
FRISBI is open to structural and molecular and cell biologists from both academia and industry from France and Europe. A simple, transparent peer reviewed process provides access based on merit and scientific priorities. FRISBI seeks to reinforce technology transfer between national and international academics and industry for technological developments and therapeutically applications.

RI Keywords
Electron microscopy, Integrative bioinformatics, Crystallography, Expression systems NMR, Nuclear magnetic resonance, Correlative microscopy, Integrative structural biology
Classifications
RI Category
Cell Culture Facilities
Bio-informatics Facilities
Structural Biology Facilities
Biomedical Imaging Facilities
Scientific Domain
Biological and Medical Sciences
ESFRI Domain
Health and Food
Services
Biophysical Characterisation

For quality control and functional analysis on protein samples.

Crystallisation

Crystallisation under anaerobic conditions; high throughput crystallisation; high throughput membrane protein crystallisation.

Data Handling and Storage
Spectroscopy

Electron spectroscopy; high field EPRh FTIR; optical super resolution spectroscopy; resonance raman spectroscopy.

Training

Training in integrative structural biology through the organization of workshops and practical courses, and national and international master's degree program.

Structural Analysis

Integrative biological approaches and expertise: NMR, X-ray crystallography, electron microscopy, imaging, correlative light and electron microscopy.

Sample Preparation

For the expression and production of biomolecules and their complexes in prokaryotic and eukaryotic system.

Equipment
Biophysical Characterisation Platform

AUC, thermal shift assay, calorimetry, MALS, circular dichroism, high pressure, microscale thermophoresis, SPR, SPRI, switchSens, thermal shift assay.

Structural Analysis Platform

NMR, X-ray crystallography, SAXS, Electron microscopy, light microscopes (confocal), correlative light and electron microscopy system, super-resolution localization microscopy.

Purification Platform

Chromatographic systems.

Access
Access Mode
Excellence Driven
Collaborations
Impact
Societal Grand Challenges
Health, demographic change and well-being
Funding
National Public Funding Organisations
Investissements d'Avenir
Date of last update: 25/10/2017