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SON NMR Large Scale Facility (SONNMRLSF)
Identification
Hosting Legal Entity
Bijvoet Center for Biomolecular Research
Utrecht University
Address:
Heidelberglaan 8, Utrecht, PO: 3584 CS (Netherlands)
Location
Padualaan 8, Nicolaas Bloembergen Building, Utrecht, PO: 3584 CH (Netherlands)
Structure
Type Of RI
Single-sited
Coordinating Country
Netherlands
Status
Status
Current Status:
Operational since 1993
Scientific Description
The SON NMR Large-Scale Facility for Biomolecular Research (SONNMRLSF) was created in 1993 at the Bijvoet Center for Biomolecular Research at Utrecht University in the Netherlands. It provides access to state-of-the-art solution state as well as solid state NMR equipment to both Dutch and international researchers. In addition to its NMR machine park, SONNMRLSF harbors an extensive computational infrastructure for Molecular Modelling, NMR structure calculations and docking simulations. The facility can also provide advanced training of young scientists.The SONNMRLSF team coordinates the national ROADMAP project uNMR-NL, the EU-funded H2020 Research Infrastructure project iNEXT (Infrastructure for NMR, EM and X-rays for Translational Research) and INSTRUCT-NL, which is a prominent member of the EU-ROADMAP Landmark INSTRUCT-ERIC. Also, the group participates in the infrastructure projects West-Life and BioExcel (computational structural biology).

RI Keywords
Proteins, Biomolecular modelling, Structural biology, NMR
Classifications
RI Category
Bio-informatics Facilities
Structural Biology Facilities
Scientific Domain
Chemistry and Material Sciences
Biological and Medical Sciences
Services
Solid state NMR

The solid state NMR infrastructure at the Bijvoet Center of Utrecht University has a 950 MHz narrow-bore, a 500 MHz wide-bore, a 700 MHz narrow-bore spectrometer and 400 MHz and 800 MHz narrow bore spectrometers with the possibility to perform DNP experiments.

Solution state NMR / protein structure determination

The solution state NMR infrastructure at the Bijvoet Center of Utrecht University group consists of a 950 MHz, a 900 MHz, a 750 MHz, two 600 MHz and a 500 MHz NMR spectrometer completely up to date with respect to current and future needs of high resolution NMR. The 950, 900 and one of the 600 MHz spectrometers are equipped with cryprobe systems for enhanced sensitivity. The 500 MHz spectrometer can be equipped with a laser system for light-related experiments.

Molecular modeling / docking simulation

Developed by the NMR spectroscopy group at the Bijvoet Center of Utrecht University, several web portals provide access to powerful software packages ported. A wide range of structural biology related software packages are available covering the many stages in NMR structure calculation, molecular dynamics simulations and structure modelling.

Equipment
900 MHz NMR (Bruker Avance III) with TCI cryoprobe
Local clusters and European Grid Initiative distributed computing infrastructure

The facility hosts about 50000 CPU-cores and 200 TB of storage for distributed computing purposes related to structural biology.

500 MHz solid state NMR (Bruker Avance III)
400 MHz solid state NMR (Bruker Avance III) with DNP
600 MHz NMR (Bruker AvanceIII)
700 MHz solid state NMR (Bruker Avance III)
500 MHz NMR (Bruker AvanceII) with laser system
750 MHz NMR (Bruker AvanceII)
800 MHz solid state NMR (Bruker Avance III) with DNP
600 MHz NMR (Bruker AvanceII) with TCI cryoprobe
950 MHz (Bruker Avance III): solution NMR / solid state NMR / micro-Imaging
Access
Access Type
Physical, Remote, Virtual, Mail-in
Collaborations
Networks
Instruct
WeNMR
Ti-COAST
European Grid Infrastructure (EGI)
DTL
Bio-NMR
iNEXT
INSTRUCT-NL
EAST-NMR
Date of last update: 19/03/2019
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