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INGESTEM - First French consortium of therapeutic innovations based on induced pluripotent stem cells (iPS cells) and human tissue engineering (INGESTEM)
Identification
Hosting Legal Entity
French National Institute of Health and Medical Research (INSERM)
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Address:
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16 avenue Paul Vaillant Couturier, Villejuif (France)
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Location
Institut André Lwoff - Bâtiment A - 7, rue Guy Môquet, U935 INSERM / ESTeam Paris-Sud, Villejuif, PO: 94800, Île-de-France (France)
Structure
Type Of RI
Distributed
Coordinating Country
France
Nodes
Provider Country:
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France
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ESTeam Paris-Sud
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I-Stem
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Instruct Center - France 1 - Institute of Genetics and Molecular and Cellular Biology (IGBMC)
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IRMB - Safe iPS
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SBRI - PrimaStem
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Status
Status
Current Status:
Operational
since 2015
Timeline
Being upgraded
since 2019
to 2019
Under construction
since 2013
to 2015
Scientific Description
Our missions are to explore the medical and industrial potential of iPS cells, and to bring innovative technology solutions by providing expertise in all stages of project development and translation.INGESTEM aims to coordinate and structure different steps involved in the development stem cells used either for drug screening or for protocols of regenerative medicine with the following strategies:- Creation of a “research” biobank of human and animal induced pluripotent stem cells (iPS) and embryonic stem cells (ES)- Development of a french registry of iPS cell lines qualified with international standards, including clinical and biological annotations- Cell and tissue engineering- Risk analysis and characterization of products from cell engineering- Standardization of protocols and automated production- Transgenic animal models- Modeling of human monogenic and polygenic genetic diseases, drug discovery by high throughput screening.- Therapeutic models with design and validation of preclinical models to the production of Advanced-Therapy Medicinal Products (ATMPs) for early clinical trials phase I-II.
RI Keywords
Biobank, Regenerative medicine, Cell based high content screening, Induced pluripotent stem cells (iPSCs), Embryonic stem cells (ESC), Animal models, Stem cells
Classifications
RI Category
Cell Culture Facilities
Scientific Domain
Biological and Medical Sciences
ESFRI Domain
Health and Food
Services
Cell Engineering
On demand cell differentiation; Genome editing; Generation of iPS cell line; Quality control tests.
Drug Discovery
High-throughput screening.
Date of last update: 28/05/2018