The Laboratori Nazionali del Sud (LNS) is one of the four national laboratories of INFN. Founded in 1976, it currently employs about 150 people (researchers, technicians, PhD and diploma students) and represents an advanced development centre for technology and instrumentation. At LNS two particle accelerators are available: a 15MV Tandem Van De Graaff that was used for the first experiments in the early 1980s, and a K800 Superconducting Cyclotron in full operation since 1996. The scientific mission of the LNS is mainly the study of nuclear collisions at intermediate and low energy, in collaboration with researchers coming from several countries. At the LNS two particle accelerators, a Superconducting Cyclotron and a Tandem, provide ion beams from Hydrogen to Lead with energies up to tens of MeV per nucleon. It is also possible to produce radioactive ion beams applying the in-flight fragmentation method. Nuclear matter properties are studied by using big detector apparata (CHIMERA, MAGNEX, MEDEA) and dedicated apparata that can be installed in one of the available experimental halls. Theoretical Physics studies are also carried out in the same research fields.For Particle Astrophysics a large undersea research infrastructure (KM3NeT) is currently under construction for the detection of neutrinos. It is located in a branch of the LNS located in Portopalo di Capo Passero, and is used also for interdisciplinary research (Geophysics, Volcanology, Marine Biology). At the LNS an irradiation hall for proton-therapy (CATANA), a laboratory for Cultural Heritage (LANDIS), a laboratory for measurements of environment radioactivity and other laboratories for interdisciplinary activities (photonics, biology, chemistry) are fully operating. LNS has a Program Advisory Committee which meets at least once a year. The PAC is composed of two nationals and five foreign members.