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Magnetic Resonance Center/Interuniversity Consortium of Magnetic Resonance Metalloproteins
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Bio-informatics Facilities
Analytical Facilities
Genomic, Transcriptomic, Proteomics and Metabolomics Facilities
Systems Biology/Computational Biology Facilities
Distributed Computing Facilities
Collections of Biological Resources (e.g. Microorganisms, Biobanks and Seed Banks)
Chemistry and Material Sciences
Spectrometers operating at field strengths ranging from 400 to 950 MHz and from 0.01 to 50 MHz. The high field instruments are equipped with cryoprobes and/or with a variety of special probes which make them unique for the structural and dynamical characterization of high molecular weight proteins, paramagnetic systems and unfolded or partially unfolded states. In-cell NMR can be used to follow protein folding and processes that are at the basis of mitochondrial function.
A 700 MHz WB and a 850 MHz WB instruments, and a narrow bore operating at 600 MHz. These instruments are ideal for the atomic level characterization of insoluble material like large protein aggregates and fibrils. At CERM-CIRMMP an innovative approach has been developed, to study soluble macromolecules, aggregates or prefibrillar oligomers by sedimenting them directly in the NMR rotor by means of exploiting its centrifugal force.
Access to da Vinci European BioBank for biological (both human and non-human) sample storage and retrieval.
Three-channel instrument equipped with TCI cryoprobe, TXI RT, TBO RT and BBI RT probes.
To study the secondary structure of proteins.
Four-channel instrument, equipped with a TXO cryoprobe for 13C direct detection with 1H, 2H, 13C and 15N decoupling.
9.43 GHz (X-Band, ElexSys E 500) and 35 GHz (W-Band, ElexSys E 580E), with low temperature ancillary equipment.
Four-channel instrument, equipped with a TXI cryoprobe, a QXI RT probe and a high-power probe for the study of fast-relaxing systems and MAS accessories for solid state studies, with 1.3 mm, 1.3 mm and 3.2 mm triple resonance probes.
Equipped with MAS accessories for solid-state studies, with 0.7 mm, 1.3 mm and 3.2 mm triple resonance probes.
Equipped with MAS accessories for solid-state studies, with 3.2 mm and 4 mm double and triple resonance probes.
High sensitivity Stelar relaxometer for the measurement of relaxation rates from 0.01 to 45 MHz proton Larmor frequency.
Integrated databases and software for genome browsing, metal binding analysis, structure calculation with/without paramagnetic constraints, sequence validation, domain organization, evolution, protein complex analysis; programs for NMR data processing and structural calculations is also provided via web, and through the Grid computing platforms.
Three-channel and 2H decoupling instrument, equipped with a TCI 1H/13C/31P cryoprobe, as well as an automatic sample changer.
Three-channel and 2H decoupling instrument, equipped with a TCI cryoprobe and TXI RT probe.
Three-channel and 2H decoupling instrument, equipped with a TCI cryoprobe.
For studying protein-ligand or protein-protein interactions.
Two-channel instrument equipped with BBO RT, BBI RT, 1H selective high power probes.
Three-channel and 2H decoupling instrument, with a TCI cryoprobe and automatic sample changer.
To study the thermodynamics of protein-ligand of protein-protein interactions.
For measuring batch samples or in-flow samples (FPLC coupling).
Equipped with HR-MAS accessories and a number of BB probes which cover a frequency range from 600 to 20 MHz.
