National Grid Infrastructure is a part of the research infrastructure for Physical and Technological Sciences of Lithuania which is owned by Vilnius University and funded by European Structural Funds.LitGrid-HPC is based on an existing HPC infrastructure at Vilnius University and on the network of distributed and parallel computing and e-services (LitGrid). It enables comprehensive scientific data maintenance. The RI is meant to create, maintain and develop an e-infrastructure (grid, cloud computing, high-performance computing, virtual repositories, related data sets), to serve the academic environment, public sector, business needs, and requests from foreign partners. It also provides calculation resources, modeling services, virtual repositories, data sets storage and usage and provide an “on demand” supply: computing, data repositories, related e-services. LitGrid-HPC deploys technological innovations or use new technologies in HPC, grid and cloud computing, especially via participation in the European Grid Initiative (EGI) and HPC activities. Supercomputing resources are open to any user according to the rules of public access centers of Vilnius University.