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Norwegian Structural Biology Centre (NorStruct)
Identification
Hosting Legal Entity
University of Tromsø
Location
Sykhusvegen 23, Tromsø, PO: 9019 (Norway)
Structure
Type Of RI
Single-sited
Coordinating Country
Norway
Status
Status
Current Status:
Operational since 2004
Scientific Description
The Norwegian Structural Biology Centre (NorStruct) is a national research and service centre within the national initiative in functional genomics (FUGE). The lab is equipped with state-of-the-art instrumentation for the full pipeline from protein production through high throughput crystallization and structure determination to drug discovery related tasks.The NorStruct facilities and competence are divided into three platforms: 'Protein production'(SP1), 'Structure determination' (SP2), and 'Drug discovery and design' (SP3), which are available to the Norwegian research community through services and collaborative projects.NorStruct also hosts students and scientists for training and research through the Guest program, and NorStruct is the administrator of a national PhD school 'BioStruct - The Norwegian Graduate School in Structural Biology'.

RI Keywords
Structural biology, Protein production, Crystallography, Protein-ligand interactions, Bioinformatics
Classifications
RI Category
Structural Biology Facilities
Bio-informatics Facilities
Chemical Libraries and Screening Facilities
Scientific Domain
Biological and Medical Sciences
Chemistry and Material Sciences
ESFRI Domain
Health and Food
Services
Protein Production

Predominantly E. coli production and chromatographic purification of proteins.

Training
Drug Discovery

Target protein modelling, Screening for protein ligands (SPR, activity assays, etc.), crystal soaking and inhibitor co-crystallography, binding data analyses.

Consulting
Crystal Structure Determination

Crystallization, X-ray data collection and crystal structure solution.

Protein Characterization

Dynamic light scattering, differential scanning calorimetry, spectrophotometers, analytical chromatography methods.

Equipment
Protein Expression Platform

Molecular biology techniques (PCR etc.), procaryotic and eucaryotic protein expression (incubation, small scale fermentation, optimization microfermentation), cell lysis.

Protein Purification Systems

A wide range of HPLC and FPLC systems.

Crystallography Platform

Automated crystallization screen mixing and plating, dynamic light scattering, nanoliter crystallization drop dispensing, automated crystal plate storage and imaging, rotating anode X-ray generation, image plate diffraction data measurement, small molecule diffractometer.

Ligand Binding Measurement Platform

Surface plasmon resonance, isothermal calorimetry, fluorimetry.

Collaborations
Networks
BioStruct-X
ELIXIR
EU-OPENSCREEN
Protein Production and Purification Platforms in Europe (P4EU)
Date of last update: 10/05/2017
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