Creation of genetically modified mouse models by transgenesis and targeted mutagenesis, production of ES cells, screening and validation of recombinated ES cells.

Mouse embryo and spermatozoa cryopreservation.

Distribution of genetically modified mouse strains.

Monitoring the health status of a mouse line (quarantine, decontamination, health/sanitary control), mouse husbandry, mouse breeding, genetic background fixation, genotyping, generation of cohorts, genetic quality control of a mouse model (validation of genetic modification, level of gene expression and tissue expression).

A panel of courses and workshops in mouse phenogenomics.

Clinical phenotyping in vivo in the following fields: anatomic-pathology, behavior, cognition, sensory systems, cardiovascular system, neuromuscular system, nutrition and metabolism, renal function, pulmonary function, embryology and reproduction, immunology, inflammation, allergy, infectiology, oncology, clinical chemistry and hematology); in vivo imaging (photonic, 2D and 3D radiologic, isotopic imaging); in vitro and in situ immunophenotyping (of innate and adaptive immune sytem under normal or confined condition).

Materials for functional exploration: HPLC, OLYMPUS AU-400 automated laboratory work station, Luminex, FACS analyser, metabolic cages, comprehensive indirect calorimetry system, exercise treadmill, NMR body composition, echocardiographs, blood pressure measurment device, plethysmograph, telemetry devices; materials for cognitive function and behavior exploration: openfield, Y- maze, Morris water-maze, slit lamp imaging, ERG, clic box; histopathology platform.

Housing and breeding rooms for mouse and rat under various health statuses (SPF, SOPF, biosafety containment from A2 to A3); various housing and breeding devices: open cages, ventilated racks; controlled environnement (controlling for temperature, light, photoperiod, food quantity, etc.).

For non-invasive exploration by molecular imaging, isotopic imaging, and radiology imaging through: bioluminiscence, fluorescence, scintigraphy, positron emission tomography, tomography opto-acoustic.

For in vivo animal model development (mouse): stereotaxis, xenograft BrainSight type neuro-navigation device; training for animal testing (mouse, pig, rabbit).

For the creation of genetically modified strains: DNA and ES cell microinjection devices; ovocyte microinjection devices; robotic (Tecan) workstations for DNA; microfluidics electrophoresis robots (Caliper), current molecular biology devices (PCR, qPCR, blots, etc.).

FACS analysers; cell sorter; cell separator; Luminex; mass cytometer; polychromatic flow cytometry devices; BSL3 live imaging (confocal and biphotonic imaging).