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The research reactor LVR-15 is a medium power light water research reactor operated by the Research Centre Řež. It is a medium power water reactor providing moderate flux of thermal neutrons at nine horizontal radial channes and vertical irradiation channels. NPL uses this facility as a source of neutrons for neutron scattering experiments and nuclear analytical methods. Five neutron scattering instruments are installed at four horizontal thermal neutron channels (HK4 HK6, HK8 and HK9) and serve primarily to resarch in the fields of material science and solid state physics. In addition, one horizontal channel (HK3) hosts special beamline for neutron depth profiling and prompt gamma activation analyses.

The isochronous cyclotron U-120M is a versatile machine operated both in positive and negative modes. It can accelerate light ions (H+, H−, D+, D−,3He+2, 4He+2) in the energy range from 1 to 55 MeV. Positive ions (H+, D+, 3He+2, 4He+2) are extracted from the cyclotron by means of three sections electrostatic deflection system with a magnetic kicker. Negative ions H−, D− are extracted by a stripping method using a thin carbon foil. A set of high-power broad-spectrum and quasi-monoenergetic neutron fields at energies up to 35 MeV are produced using ion-beam reactions on special neutron source targets.

The accelerator Tandetron 4130 MC, put into operation in 2005, is a source of accelerated ions of most of elements from H to Au with energies from 0.4-20 MeV and intensities up to tens of mA. The main laboratory accessories are devices for material characterization by standard nuclear analytical techniques (RBS, RBS-channeling, ERDA, ERDA-TOF, PIXE, PIGE, and Ion-Microprobe with 1 μm lateral resolution) and for high-energy implantation. In the laboratory there are several other devices intended mostly for preparation of micro- and nano-structures using different deposition techniques and for their characterization by other complementary methods (e.g. AFM).