Training on and maintenance of available light microscopes (commercial and developed) at facility.

High throughput sequencing of libraries on Illumina sequencers, first and second level bioinformatic support.

Specimen preparation via chemical fixation and embedding.

Provision of numerous environmental plant growth conditions: Standard growth conditions, frost (down to -15°C), high-temp. (up to 50°C), adjustable light spectrum (LED), different gas conditions, fully automated watering…, Air-Lock System equipped chamber for pathogen infestation experiments; Large Capacity Chamber; Seed Storage Chamber.

Providing innovative and intuitive software solutions that solve general as well as individual needs for laboratories including scientific and laboratory data management as well as automated data analysis and reporting tools.

Purification of recombinant protein for research purposes.

Ultrahigh field magnetic resonance imaging at 15.2 T for advanced anatomical and functional characterization of transgenic (mouse) models, both for whole animal screening and for focusing on specific organs; qualitative and quantitative image analysis.

Transmission electron microscopy of frozen hydrated specimens (cells, viruses, molecules).

Immunolabelling of cryosectioned material for Transmission EM.

Generation of sequencing libraries and quality control.

Development of custom high end light microscopy solutions for biomedical research purposes.

Developing and implementing hardware-related software for biological experiments using embedded and robotic systems.

Specimen preparation via high pressure freezing and freeze substitution.

Biochemical and biophysical characterization of proteins, using techniques such as Simple Western, Microscale Thermophoresis, and Circular Dichroism.

Recombinant protein production in E. coli or insect cells for research purposes.

Robotic, non-destructive plant phenotyping.

Behaviour: spontaneous behavior, motor analysis learning-memory, anxiety-depression, social interactions, pain; Metabolic function: Drinking/feeding behavior, calorimetry, environmental challenges; Neuro-physiological functions: ECG, blood pressure, EEG/EMG.

Provision of state-of-the-art nanoHPLC-MS/MS systems for protein identification, posphomapping and quantification.

Providing longer general courses and shorter specific trainings as well as consultation support in the fields of biostatistics, programming and bioinformatics by both external and internal experts.

Sampling of embryos, perfusion, necropsy, tissue paraffin or cryo-embedding, sectioning of paraffin or cryo blocks, automated basic staining, immunostaining, pathology report.

Developing, implementing and applying advanced data analysis tools and novel approaches for the analysis of high-throughput data set generated mainly by next-generation sequencing instruments. The core works closely with the CSF Next-generation sequencing (NGS) facility and provides consultation and downstream data analysis for various NGS applications.

FEI Morgagni: 100 kV TEM FEI Tecnai 20: 200 kV TEM for electron tomography FEI Tecnai F30 Helium ('Polara'): 300 kV FEG TEM for cryo-TEM, electron tomography and EELS.

FPLC systems for protein purification.

Instrument for automated analysis of proteins via capillary electrophoresis combined with immunodetection.

Bruker 152/11 BioSpec (http://www.bruker.com/fileadmin/user_upload/8-PDF-Docs/MagneticResonance/MRI/brochures/152-11_mouse_T138908.pdf).

Comprises all equipment necessary for culturing of insect cells.

22 high quality, state of the art and highly specialized plant growth chambers: fully automated watering, LED-Chamber for adjustable light spectrum, 4 Frost-Chambers (down to -15°C), High-temp.-Chamber (up to 50°C), Large Capacity Chamber, Air-lock System Chamber, 2 Gas-tight Chambers for different gas conditions, Plant Phenotyping Chamber, Seed Storage Chamber.

Microtime 200 by Picoquant, with 440nm & 510nm pulsed excitation diodes.

Several instruments for biophysical characterization of proteins, including analysis of protein-protein interactions and protein secondary structure.

12 cage Phenomaster with climate chamber, Motorater, telemetry, 2 video tracking systems, open field, different mazes, fear conditioning, operant learning, analgesia equipment (dynamic plantar test for touch sensitivity and Hot/Cold plate).

Deltavision OMX v4 (Applied Precision/GE Healthcare), with 405nm, 488nm & 568nm excitation lasers.

nanoHPLC-MS systems: 3 Thermo Q-Exactive, 3 Thermo LTQ Orbitrap VELOS+ETD, ABI Triple 5600, AB SCIEX QTrap 5500.

2x Genome Analyzer IIx (Illumina), 1x HiSeq 2000 (Illumina), 1x HiSeq 2500 (Illumina).

Leica EM GP: Immersion freezer for cryo-TEM Bal-Tec MED050: High vacuum evaporator with electron guns Bal-Tec BAF400: Freeze fracture unit Leica EM PACT: High pressure freezer * HFP Compact 001: High pressure freezer.