Purification of recombinant protein for research purposes.

Transmission electron microscopy of frozen hydrated specimens (cells, viruses, molecules).

Generation of sequencing libraries and quality control.

Providing longer general courses and shorter specific trainings as well as consultation support in the fields of biostatistics, programming and bioinformatics by both external and internal experts.

Robotic, non-destructive plant phenotyping.

Development of custom high end light microscopy solutions for biomedical research purposes.

Training on and maintenance of available light microscopes (commercial and developed) at facility.

Biochemical and biophysical characterization of proteins, using techniques such as Simple Western, Microscale Thermophoresis, and Circular Dichroism.

Specimen preparation via chemical fixation and embedding.

Specimen preparation via high pressure freezing and freeze substitution.

Developing and implementing hardware-related software for biological experiments using embedded and robotic systems.

Sampling of embryos, perfusion, necropsy, tissue paraffin or cryo-embedding, sectioning of paraffin or cryo blocks, automated basic staining, immunostaining, pathology report.

Developing, implementing and applying advanced data analysis tools and novel approaches for the analysis of high-throughput data set generated mainly by next-generation sequencing instruments. The core works closely with the CSF Next-generation sequencing (NGS) facility and provides consultation and downstream data analysis for various NGS applications.

High throughput sequencing of libraries on Illumina sequencers, first and second level bioinformatic support.

Ultrahigh field magnetic resonance imaging at 15.2 T for advanced anatomical and functional characterization of transgenic (mouse) models, both for whole animal screening and for focusing on specific organs; qualitative and quantitative image analysis.

Immunolabelling of cryosectioned material for Transmission EM.

Recombinant protein production in E. coli or insect cells for research purposes.

Provision of numerous environmental plant growth conditions: Standard growth conditions, frost (down to -15°C), high-temp. (up to 50°C), adjustable light spectrum (LED), different gas conditions, fully automated watering…, Air-Lock System equipped chamber for pathogen infestation experiments; Large Capacity Chamber; Seed Storage Chamber.

Provision of state-of-the-art nanoHPLC-MS/MS systems for protein identification, posphomapping and quantification.

Providing innovative and intuitive software solutions that solve general as well as individual needs for laboratories including scientific and laboratory data management as well as automated data analysis and reporting tools.

Behaviour: spontaneous behavior, motor analysis learning-memory, anxiety-depression, social interactions, pain; Metabolic function: Drinking/feeding behavior, calorimetry, environmental challenges; Neuro-physiological functions: ECG, blood pressure, EEG/EMG.

22 high quality, state of the art and highly specialized plant growth chambers: fully automated watering, LED-Chamber for adjustable light spectrum, 4 Frost-Chambers (down to -15°C), High-temp.-Chamber (up to 50°C), Large Capacity Chamber, Air-lock System Chamber, 2 Gas-tight Chambers for different gas conditions, Plant Phenotyping Chamber, Seed Storage Chamber.

Deltavision OMX v4 (Applied Precision/GE Healthcare), with 405nm, 488nm & 568nm excitation lasers.

Instrument for automated analysis of proteins via capillary electrophoresis combined with immunodetection.

2x Genome Analyzer IIx (Illumina), 1x HiSeq 2000 (Illumina), 1x HiSeq 2500 (Illumina).

FEI Morgagni: 100 kV TEM FEI Tecnai 20: 200 kV TEM for electron tomography FEI Tecnai F30 Helium ('Polara'): 300 kV FEG TEM for cryo-TEM, electron tomography and EELS.

Comprises all equipment necessary for culturing of insect cells.

Several instruments for biophysical characterization of proteins, including analysis of protein-protein interactions and protein secondary structure.

Bruker 152/11 BioSpec (http://www.bruker.com/fileadmin/user_upload/8-PDF-Docs/MagneticResonance/MRI/brochures/152-11_mouse_T138908.pdf).

Leica EM GP: Immersion freezer for cryo-TEM Bal-Tec MED050: High vacuum evaporator with electron guns Bal-Tec BAF400: Freeze fracture unit Leica EM PACT: High pressure freezer * HFP Compact 001: High pressure freezer.

nanoHPLC-MS systems: 3 Thermo Q-Exactive, 3 Thermo LTQ Orbitrap VELOS+ETD, ABI Triple 5600, AB SCIEX QTrap 5500.

12 cage Phenomaster with climate chamber, Motorater, telemetry, 2 video tracking systems, open field, different mazes, fear conditioning, operant learning, analgesia equipment (dynamic plantar test for touch sensitivity and Hot/Cold plate).

Microtime 200 by Picoquant, with 440nm & 510nm pulsed excitation diodes.

FPLC systems for protein purification.