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Integrated Structural Biology Infrastructure for Europe (INSTRUCT-ERIC)
Hosting Legal Entity
Self-standing RI
Legal Status
John Smith Drive, Oxford House, Oxford, PO: OX4 2JY (United Kingdom)
Type Of RI
Coordinating Country
United Kingdom
Participating Countries
United Kingdom
Czech Republic
Provider Country:
Provider Country:
Czech Republic
Biotechnology and Biomedicine Center of the Academy of Sciences and Charles University in Vestec (BIOCEV) | Central European Institute of Technology (CEITEC)
Provider Country:
Instruct Center - France 1 - Institute of Genetics and Molecular and Cellular Biology (IGBMC) | Instruct Centre - France 2 - Integrated Structural Biology Grenoble (ISBG)
Provider Country:
Centre for Bioinformatics | The Dana and Yossie Hollander Center for Structural Proteomics (ISPC) Weizmann Institute of Science (WIS) Israel (ISPC (WIS) Israel)
Provider Country:
Instruct Centre - CERM/CIRMMP Italy
Provider Country:
Bijvoet Center - UU | Instruct-NL | Protein facility - The Netherlands Cancer Institute (Protein facility - NKI)
Provider Country:
Centre for Image Processing
Provider Country:
United Kingdom
Centre for Computational Biology | Diamond Light Source | Molecular Biophysics Suite | Oxford Centre for Mass Spectrometry | Oxford Particle Imaging Centre (OPIC) | The Division of Structural Biology (STRUBI) | The Oxford Protein Production Facility (OPPF)
Current Status:
Operational since 2012
Under construction since 2008 to 2012
Scientific Description
Instruct is the dynamic hub of structural biology providing an integrated infrastructure of cutting-edge technology, scientific expertise and pioneering training. Its aim is to provide strategic leadership for structural biology in Europe by promoting an integrated approach to technology and methodologies.

Instruct provides structural and cell biologists from both industry and academia the opportunity to further their research with cutting-edge technologies sited at Instruct Centres across Europe. A simple, transparent peer reviewed process allocates access based on merit and scientific priorities.

The expert support and training available through Instruct ensures research is productive and that technology is used to optimal effect. This includes training in the use of the technology platform itself. Instruct's workshops, conferences, secondments, PhD programme and fellowships, in partnership with world-leading companies, all focus on promoting and developing innovative, integrated approaches to structural biology.

Instruct works with the companies that manufacture the machines used by structural and cell biologists. It helps them to develop, test and optimise new technologies that will spur breakthroughs in biology. Instruct also provides funding for academic pilot projects in this field.

Instruct is fostering the sharing of ideas and resources through the Instruct Hub; a thriving online community of researchers from across Europe and beyond who share a passion for pushing the boundaries of existing scientific disciplines and expertise.

Instruct began in the European Research Infrastructure Preparatory Phase of the ESFRI roadmap, followed by a transitional phase and into the operational phase from 2012. Instruct was recognised as a Landmark Project on the 2016 ESFRI Roadmap.

RI Keywords
Structural imaging, Crystallography, Microscopy, Access, Grants, European research infrastructure, Structural, NMR, Biology, Bioinformatics, Metalloproteins, Computational, Protein purification, Imaging, ERIC, Mass spectrometry, Cryo-transmission electron microscopy (Cryo-TEM), Protein expression, Membrane proteins, Research infrastructure, Data, Protein characterization, Protein structure determination, Mass spectroscopy, Solid-state NMR, 3D cryo-EM, Structural analysis, Cryo-TEM, Integrative, Research, Sample preparation, Expertise, Integrative structural biology, Spectroscopy, Protein production, Structural biology, Training
RI Category
Structural Biology Facilities
Biomedical Imaging Facilities
Bio-informatics Facilities
Analytical Facilities
Scientific Domain
Biological and Medical Sciences
ESFRI Domain
Health and Food
Access to Structural Biology Platforms

Instruct's centres offer a complete set of services and technologies for the integrated structural biology research process including - Sample preparation - Biomolecular analysis - 3D Structural analysis

Training for Structural Biologists

Instruct offers a range of workshops delivered at Instruct Centres by internationally recognised experts. Our education programme aims to train European scientists in a raft of structural biology technologies, not just one specialism. These researchers will be able to integrate different technologies to open up new areas of research.

State of the Art Structural Biology Platforms
Access Mode
Market Driven, Excellence Driven
RI is an ESFRI landmark
Date of last update: 24/01/2019